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In some cases, safe doses of cortisol and DHEA may be recommended to restore normal hormone levels

Conversely, while inflammatory mediators can induce metabolic reprogramming, the fundamental driver of persistent inflammation lies in metabolic reprogrammingwith metabolites such as lactate sustaining and amplifying inflammatory states to form a pathological loop (112, 113)

SlominskiATKimTKJanjetovicZBroynaAAmijewskiMAXuHet al

Copper metabolizing MURR1 domain 3 (COMMD3) is a crucial regulator of copper metabolism, and its expression levels are closely correlated with intracellular copper ion concentrations (149, 150)