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On the other hand, greater intra-tumoral expression of VEGFR-3 may predict better response, while overexpression of VEGFR1 mainly indicates poor survival [192]

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(101(26)):e29226 doi:10.1097/MD.0000000000029226

As a result, two things happen with B12 deficiency: Homocysteine levels rise because there is less THF available for the reaction that converts homocysteine to methionine and MMA levels rise because vitamin B12 is required to convert methylmalonyl-CoA to succinyl-CoA