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An athlete needing dialysis treatment requires a Therapeutic Use Exemption

Spermidine directly suppresses hepatic stellate cell activation, reducing ECM production and promoting lipid droplet restoration, thereby limiting fibrotic remodelling

through ligand traps of TGF- superfamily molecules, blocking SMAD2/3 signalling, hepcidin analogues, and inhibition of Janus kinase 2), and achieving cure through gene therapy (-globin gene addition) or genome editing (upregulating -globin and foetal haemoglobin)

10 Since then, several case series and randomized controlled trials (RCTs) have supported the use of onabotulinumtoxinA in individuals with medically refractory TN