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Rather than targeting appetite or hormones, MOTS-c primarily affects cellular metabolism

The heart-brain axis (HBA) disorders The HBA constitutes a bidirectionally interconnected neurohumoral interface, mediated by autonomic neural circuits, endocrine-cytokine cross-talk, and hemodynamic signaling networks, which collectively underpin the pathophysiology of shared cardio-cerebral disorders

Preclinical research suggests that by inhibiting NNMT, 5-Amino-1MQ may prevent the "waste" of Nicotinamide, thereby supporting higher intracellular NAD+ levels