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10.1016/j.lfs.2021.119420 82 RenJ.LiJ.LiuX.FengY.GuiY.YangJ.et al (2016)

Simultaneously, the hepatoprotective effect is doubly relevant: it addresses hyperthyroidism-induced hepatic dysfunction and also protects against drug-induced or metabolic-associated liver injury in diabetic patients

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Ethacrynic acid was the first GST inhibitor shown to possess promising inhibitory activity in vitro, however, its clinical use was limited due to adverse effects and restricted isoenzyme specificity (Tew and Gate 2001)