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Description

As well as protecting our cells from damage, glutathione is also needed to ensure effective detoxification pathways, produce energy in the mitochondria, support brain health and shore up immune function

Consistent with the reduced in vitro binding, in TFG-depleted HEK293T cells reconstituted with exogenous TFG constructs, both PB1-deleted and CC-deleted TFG failed to support lysosomal CHMP4BmNG recruitment upon LLOMe treatment (Extended Data Fig