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Metformin enhances autophagy and reduces tau and amyloid- pathology in AD models, 382 while AICAR reduces -synuclein aggregation and improves motor function in PD models

This can cause fatigue, pale skin, and shortness of breath, as the body struggles to transport oxygen efficiently

EMBO J 22(12):30153026

Despite the lack of sufficient and solid information on this topic, the following sections attempt to discuss the current evidence supporting hypothetical theoretical frameworks that connect dysbiosis with ME/CFS (see Fig