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PLoS ONE 4 , e4664 (2009)

2016;5:e11612

In order to match our mechanistic studies in rats with the human findings reported above, we next tested rats in an effort-based reward-incentivized task, the operant conditioning-based progressive ratio (PR)

With the oxygen free radicals or nonradical species attack, PUFAs will be oxidized to lipid peroxyl radicals and hydroperoxides, eventually lead to the cell membranes damage and cell death [16,17,18]