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For instance, cholesterol in tumors can cause CD8 + T cell exhaustion by triggering endoplasmic reticulum stress and activating XBP1 (139)

Pluskal, T., Nakamura, T., Villar-Briones, A

Achieving sustainable aquaculture: Historical and current perspectives and future needs and challenges

Furthermore, the histone lysine methyltransferase SETD1A contributes to sorafenib resistance, suggesting that targeting SETD1A could improve therapeutic outcomes in HCC [111]