glutathione s-conjugate X-ray structure of S-transferase from the malarial parasite Plasmodium falciparum glutathione S-transferase

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Additionally, ROS act as second messengers, activating various signal transduction pathways that can lead to cellular and tissue damage, organ dysfunction, and even carcinogenesis

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N6-methyladenosine (m 6 A) demethylase FTO is significantly upregulated in MPP + -stimulated SK-N-SH cells, which suppresses YTH domain family protein 2 (YTHDF2) expression, promotes m 6 A demethylation of BRCA1-associated protein 1 (BAP1) and enhances BAP1 expression, upregulates p53 expression, and inhibits SLC7A11 transcription, thereby increasing MDA, Fe 2+ , and 4-HNE levels and triggering neuronal ferroptosis