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In general, benchmark chemicals (Akemi, Acrylate copolymer, BE PVM/MA, PHMG, and BAC) and reference materials (LPS, Isoproterenol, and TNF-) produced differentially modulated cytokines and chemokines release over the 12-day experimental period (Table 4

The incidences of ALT and AST increases were 37% and 22%, respectively, in the omaveloxolone arm versus 2% each in the placebo arm (Table 1) [16, 20, 22]

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Functional experiments were performed in a human hepatic cell line using quantitative real-time PCRs, western blotting, and BrdU assays