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The neuroprotective effects of the ketogenic diet further extend to synaptic plasticity regulation: by increasing -hydroxybutyrate (BHB) levels, it directly activates the ERK/CREB signaling pathway in the hippocampus, promoting brain-derived neurotrophic factor (BDNF) synthesis (especially in females) to restore impaired long-term potentiation (LTP) in Alzheimers model mice

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Depending on your goals, your practitioner may recommend a structured course of treatments followed by maintenance sessions where appropriate

This dual dysfunction of microglia and astrocytes leads to extensive oxidative stress, immune activation, and eventual neuronal degradation