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4 Effect of oxidative stress on diabetic cognitive dysfunction 4.1 Overview of oxidative stress Oxidative stress is a classical biological process and refers to a redox imbalance state in which oxidants such as ROS are produced in excess with impaired antioxidant defense systems in the body ( - production and antioxidant defense systems, and superoxide dismutase (SOD) is an important O2 - natural scavenger in vivo ( 2 O 2 ) can be further degraded into water and oxygen by catalase (CAT) or glutathione (GSH) redox systems