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Hui 2009) increasing the release of adenosine, which has antinociceptive properties (Goldman 2010) inducing antinociception by activating the opioid pathway (Almeida 2008a) or the L-arg/NO/cGMP pathway (Almeida 2008b) exciting or inhibiting the anterior temporalis muscle via reflex pathways and thus smoothing jaw opening and closing (Wang 2007) You can read more on the subject here