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The study of RNA-based NPs for programmable immunomodulation in treatments is motivated by the fact that RNAs can fold into intricate 3D structures to accomplish their many activities [89]

The duration may vary depending on the treatment protocol and individual needs

These three biological states appear to be able to influence one another in a self-sustaining cycle (Nguyen et al., 2011) forming a neurotoxic triad. Figure 1 illustrates the self-sustaining interaction between excitotoxicity, oxidative stress, and inflammation (which are reviewed below), while also presenting some nutritional deficiencies which can fuel the triad

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