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Alternatively, NAM can also be generated by the direct cleavage of NAD + , generating diverse ADP-ribose metabolites [26]

Analysis of the content of the uropod in RA T cells has revealed the displacement of mitochondria into a perinuclear position ( Figure 4 Metabolic Networks as Therapeutic Targets Immunomodulatory therapies currently applied in RA have metabolic side effects ( Table 1 )