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doi: 10.1016/J.JFDA.2018.12.012 42 DingQ.MoZ.WangX.ChenM.ZhouF.LiuZ.et al

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There is around a 2.5-fold increase in B12 deficiency incidence in those treated with metformin, and this may occur as early as 3 months, although hepatic stores of vitamin B12 may take 5 years or more to deplete (Bell, 2022)

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