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Description

Through several mechanisms, including direct interaction with SUR1 and membrane depolarization, intracellular calcium mobilization, and insulin granule priming modification, EPAC2 activation may promote the exocytosis of insulin granules [55, 56]

Roessler, C., Tting, C., Meleshin, M., Steegborn, C

Krebs LT, Kramar EA, Hanesworth JM, Sardinia MF, Ball AE, et al

If any of these changes appear, the solution should not be considered reliable for continued research use, regardless of how much time has technically elapsed since reconstitution