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PMID: 40930476 J Cell Mol Med Melatonin Synergises the Chemotherapeutic Effect of Temozolomide in Glioblastoma by Suppressing NF-B/COX-2 Signalling Pathways

However, the route matters: plasma GHK-Cu circulates systemically, while topical GHK-Cu formulations face a bioavailability challenge penetrating the stratum corneum barrier to reach dermal fibroblasts