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Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P1084 - ESOC25-1890 The safety and effiCacy of HIbernation-Like therapy combining recanaLization in ischemic stroke(CHILL-1): a phase 1, dose-escalation study Shuaili Xu 1 , Qi Wang 2 , Di Wu 3 , Xunming Ji 2 1 Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China, 2 Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China, 3 China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China Background and Aims: Torpor or hibernation is characterized as a status of hypothermia and hypometabolism, helping animals survive harsh environment