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We reported biliary epithelial senescence and dysregulated autophagy in the bile duct lesions such as chronic non-suppurative cholangitis (CNSDC) and ductular reactions (DRs) and their possible involvement in the pathogenesis of PBC via senescence associated secretory phenotypes (SASPs)

With advances in mechanistic understanding and translational tools, ferroptosis is poised to become a promising therapeutic breakthrough in the precision treatment of Alzheimers disease

Discovery of a novel oral proteasome inhibitor to Block NLRP3 inflammasome activation with anti-inflammation activity

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