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Therefore, combining FSP1 inhibitors may represent an effective therapeutic strategy for ferroptosis in Keap1 -deficient lung cancer and cancers with radioresistance

Interestingly, RIPK1 kinase activation, as marked by its autophosphorylation of S166, was suppressed in the presence of HK2 protein, suggesting that HK2-mediated phosphorylation direct inhibits RIPK1 kinase activation (Fig