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Common and distinct serum metabolomic dysregulations across pathogenic mutations in GBA1, LRRK2, TMEM175, and PARK2-PINK1-PARK7 in both sexes Importantly, multivariate analysis of the NMR-based dataset revealed that the serum profiles of PD patients, categorized by genotype and sex, did not show distinct metabolic signatures ( Fig

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Disruption of the gut microbiota early in life, for instance via antibiotic exposure, can result in long-lasting changes to visceral pain sensitivity and stress responsiveness, as demonstrated in rodent models (O'Mahony et al., 2014

Samaridou E, Walgrave H, Salta E, lvarez DM, Castro-Lpez V, Loza M, et al