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Although the general mechanisms of APAP-induced liver injury appear to be very similar in the 2 substrains [132], the risk for experimental design is that there is a mismatch in the substrains between WT and KO mice, which can lead to misinterpretation of the data

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Autophagy, a key catabolic process involving the degradation and recycling of cellular components, is intricately regulated by mTORC1 21