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Hepatocyte Growth Factor Augments the dendritic architecture and Supports Synaptogenesis Dihexa and Nlel -AnglV have previously been .shown to induce spinogenesis in mRFP-p-actin transfected hippocampal neurons (see Example 1)

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However, this mechanism requires the presence of susceptible substrates

For perimenopause specifically, hormonal fluctuation drives many of the most disruptive symptoms estrogen can spike and crash erratically, which is why some patients feel worse in early perimenopause than in full menopause