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doi: 10.1016/j.jalz.2016.10.003 161 PerezGrovas-SaltijeralARajamaniAPRKnightHM

Accordingly, serine deprivation or SSP blockade restores the sensitivity of colorectal cancer cells to 5-FU ( 6.2.2 Targeted therapy resistance 6.2.2.1 BRAF inhibitor resistance Proteomic analysis of acquired-resistance cell lines revealed altered expression of serine biosynthetic enzymes (PHGDH, PSPH, PSAT1) in drug-resistant cells