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If pain is not tolerable, you can use over-the-counter pain relief like paracetamol

Disturbances in the gut microbiome , or changes in the natural balance of bacteria in the intestines, may contribute to the development of irritable bowel syndrome

[] According to these studies, it seems that IWS incidence from opioids tends to be higher in trauma and surgical critically ill patients, those who receive rapid infusion rate, and the type of opioids (such as fentanyl and morphine)

The effects of xanthine oxidase inhibitor in patients with chronic heart failure complicated with hyperuricemia: a prospective randomized controlled clinical trial of topiroxostat vs allopurinol-study protocol