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Jourkesh et al

Differential gene expression in wild type and cir1 plants without pathogen challenge were examined using a microarray biased toward defense-response and signaling genes in order to identify transcripts required for resistance

In a healthy individual, the body's antioxidant reservesled by glutathionequickly sweep in to neutralize these free radicals once the infection clears

In plants, glutathione fulfills a broad range of essential functions including detoxification of heavy metals and xenobiotics and serving as an electron donating cofactor in biochemical reactions (Cobbett and Goldsbrough, E GSH depends on the absolute glutathione concentration and the ratio of [GSH]:[GSSG] (Meyer and Hell, E GSH is assumed to affect the glutathionylation status of proteins which is an important means of regulating protein activity (Michelet et al., Conditions of environmental challenge are frequently considered to cause the generation of oxidants in the form of reactive oxygen species (ROS) (Apel and Hirt, E GSH caused by a transient draw of electrons from the glutathione redox buffer for oxidant detoxification and coupling of E GSH to target proteins thus may result in altered protein function and hence pronounced metabolic and developmental consequences for individual cells and the whole organism