female network oral glutathione Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity: Cell The effects of the – A Targeted Metabolomic Assessment of

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Animal model research demonstrated that depleting GSH via inhibition of GCL triggered a cascade of lipid peroxidation and cell death in mesencephalic cultures, identifying oxidative stress from glutathione insufficiency as a likely initiating mechanism in neurodegeneration

Disclosures: Kezia Hobson: Perspectum Ltd: Employee, Dylan Windell: Perspectum: Employee, asd: Employee, Paul Aljabar: Nothing to Disclose, George Ralli: Nothing to Disclose, Rob Goldin: Nothing to Disclose, Kenneth Fleming: Nothing to Disclose, Caitlin Langford: Nothing to Disclose 775 HISTOLOGICAL DIAGNOSTIC TOOL FOR DETECTING AND CHARACTERISING PORTAL TRACTS IN LIVER DISEASE USING ARTIFICIAL INTELLIGENCE Dylan Windell 1 Alastair Magness 1 Abhishek Roy 1 Paul Aljabar 1 Timothy Kendall 2 Eve Fryer 3 Kenneth Fleming 4 Rob Goldin 5 Caitlin Langford 1 , 1 Perspectum, 2 University of Edinburgh, 3 Oxford University Hospitals NHS, 4 University of Oxford, 5 Imperial College London Background: AI- driven digital workflows for liver biopsy grading and staging have the potential to produce more accurate and reproducible results than traditional assessments

Moving toward a systems-level understanding, empowered by interactomics, CRISPR technologies, AI-driven modeling and precision biomarker science, will profoundly transform how we interpret disease biology and develop therapeutics