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However, curcumin may increase the risk of bleeding in people taking warfarin and antiplatelet drugs, and can potentiate the effect of other medications such as antibiotics, anti-inflammatories, and chemotherapy agents, therefore some caution is warranted when used in combination with these medications [3, 198]

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Finally, the Turkish kindred have a single base deletion in exon 5, causing a frame shift mutation with complete loss of enzymatic activity (10, 11)