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Ceisler EJ, Bilyk JR, Rubin PAD, Burks WR, Shore JW

NFATc1, but not NFATc2, is required for CD8 + T cells to engage in the T cell activation-induced metabolic switch to glycolysis [185]

39o Congreso Nacional de Oncologia

While immune-mediated hepatitis results from overactivation of cytotoxic CD8+ T cells, which infiltrate hepatic lobular regions and mediate direct hepatocyte injury, TKI-related hepatic dysfunction is associated with direct hepatic effects from VEGFR inhibition leading to microvascular injury and dysregulation of fibrogenic pathways ( Therefore, attribution of toxicity may require temporary discontinuation of one or both agents, guided by AE severity, followed by close clinical monitoring to assess reversibility