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doi: 10.3389/fnut.2025.1577369 Received 15 February 2025 Accepted 07 May 2025 Published 09 June 2025 Volume 12 - 2025 Edited by Giacomo Di Matteo, Sapienza University of Rome, Italy Reviewed by Massimo Frangiamone, Universit de Lausanne, Switzerland Tamara Hoppenbrouwers, Wageningen University and Research, Netherlands Updates Copyright 2025 Bietto, Arranz, Miralles, Gmez-Marn, Rath, Lucey and Giblin

Its effects, if any, are subtle and take time to manifest at a cellular level

However, aberrant activation of this pathway disrupts TJs, causing increased BBB leakage in CNS diseases [76, 77]

Pomfrett CJD, Dolling S, Anders NRK et al (2009) Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia