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These twenty-five pathways are: TLR signaling, NOX signaling, TNF- signaling, IL-33 signaling, IL-4 signaling, IL-12/IFN signaling, IL-6/TGF signaling, IL-17 signaling, IL-2/TGF signaling, NO signaling, IL-13 signaling, EGFR signaling, TGF- signaling, VEGF signaling, MMP-9 signaling, IL-10 signaling, CCR3 signaling, TRPV1 signaling, acetylcholine signaling, SP signaling, CRH signaling, NE/IL-1 signaling, Epinephrine signaling, glucocorticoid signaling, and IL-23 signaling

d n, KL1 showed consistent adjuvant activity across multiple MRSA and MSSA isolates: MW2 ( d ), SA03739 ( e ), SA03740 ( f ), SA03758 ( g ), SA03775 ( h ), SA03803 ( i ), SA03809 ( j ), SA03815 ( k ), SA03833 ( l ) and SA03850 ( n ), but not SA03847 ( m ), which was highly Rif-resistant (Supplementary table 1)

The underlying mechanism why the compound exhibited the selective cytotoxicity toward tumor cells over non-tumor cells are not fully understood, but it might have reflected the alterations of GST activities in the cells 30 , and the detailed study along this line is currently ongoing