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While our study highlights the significance of hepsin in the context of liver protection and its potential therapeutic implications in APAP-induced hepatotoxicity, there are limitations to consider when evaluating hepsin as a candidate drug or therapeutic strategy

Moreover, glutamine plays a pivotal role in the metabolism of nontumor cells

L-glutamine helps to actively calm this immunological storm by directly inhibiting the activation of Nuclear Factor-kappa B (NF-B), a primary, highly aggressive transcription factor that drives the massive production of highly destructive pro-inflammatory cytokines like Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-)

Interestingly, the rate-limiting substrate for GSH synthesis in Mller glial cells is glutamate, and not cysteine 66,67,68