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However, excessive cholesterol accumulation disrupts this equilibrium and contributes to metabolic disorders, including cardiovascular disease, type 2 diabetes mellitus (T2DM), and MASLD [18]

R., Klotz, L

In respect of physiological volumes of the brain fluids, V u,brain of 0.2 mL/g brain is the lowest possible value, which is equal to ISF volume, V brain,ISF (102), while V u,brain close to the 0.8 mL/g brain displays the water volume in the brain indicating an even distribution within the brain (103)