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in the mid-1930s [26], (b) produced mainly by fibroblasts [27], (c) to date consists of 28 types, numbered from IXXVIII, constituting about 8090% (type I) and 1015% (type III) in human skin [27], (d) provides tensile strength and elasticity to withstand mechanical forces in everyday activities [26,27,28,29], and (e) mainly composed of the amino acids glycine (Gly), proline (Pro), and hydroxyproline (Hyp), along with its typical triple-helix structure [26, 27, 29]

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