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Obviously, a growing body of preclinical evidences suggests that the induction of lipid peroxidation by inhibiting system x c - might be an effective therapeutic strategy to clear cancer cells and prevent the acquired resistance to several cancer drugs, such as lapatinib, dabrafenib and vemurafenib (Table S1) [228, 261, 262]

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The measurement of serum and urine carboxy-terminal cross-linking telopeptide of type I collagen (CTX-1), a marker of bone resorption, has been proposed as a method of evaluating the risk of ONJ as a result of bisphosphonate usage, although they are not commonly measured in the clinical setting