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Clinical trials involving positron emission tomography (PET) with translocator protein expressed by activated microglia (TSPO) have demonstrated that seizures, temporal lobe epilepsy, frontal lobe epilepsy, and focal cortical dysplasia are associated with neuroinflammation, and their acute onset leads to chronic neuroinflammation and exacerbates its deterioration (145)

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Carnosine exerts neuroprotective effects in neurodegenerative diseases (such as AD and PD) by targeting multiple pathological processes, including oxidative stress, inflammation, neurotransmitter imbalance and abnormal protein aggregation (56,57)

It is most active in steroid-producing tissues, red blood cells, and the liver