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Enzyme replacement therapy for hypophosphatasia has shown promising results in human clinical trials, reducing mortality in hypophosphatasia and improving chondromalacia, lung function and exercise milestones in these patients [44]

doi: 10.3390/ijms232113035 77 LiJ.HouB.TumovaS.MurakiK.BrunsA.LudlowM

Nov 17 2021;13(11)doi:10.3390/nu13114126

If prevention fails, holistic and personalized management should be taken as soon as possible through timely detection and diagnosis, considering target organ protection, comorbidities, treatment goals, and other factors in reality