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In conclusion, by targeting senescence, we offer a strategy that simultaneously decreases radioresistance of [nonsmall cell lung cancer] and the incidence of RIPF. Not only were the fibroblasts (cells commonly found in connective tissue) more susceptible to radiation therapy treatment instead of being more resistant to it, but it also treated damage and scarring to lung tissue induced by radiation therapy

2021 (Nature Reviews Mol Cell Biol) document age-related NAD+ decline and the biology that drives clinical interest

For most patients, this is a welcome change that accelerates their weight loss and improves overall metabolic health

Insulin levels during the glucose tolerance test were substantially lowered in the calorie-restricted mice and in mice treated with GLP-1MK-801 (Extended Data Fig