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Dieckol, a significant antioxidant, serves as the primary bioactive component of purified polyphenolic extract from Ecklonia cava an edible brown alga found mainly in China, South Korea, and Japan (Li et al

PMID: 35146015

In particular, systematic investigations of exposure concentration, particle size, surface chemistry, and exposure duration are needed to establish dose response relationships and threshold effects in reproductive tissues

Importantly, Nrf2 improves the survival rate of joint cells by regulating apoptosis and autophagy and reducing drug-induced apoptosis, thereby protecting the joint from further damage and potentially promoting tissue repair