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While our mechanistic data and mouse model results are compelling, a formal statistical causal inference or randomized controlled design would be required to definitively attribute hyperprogression to the immunotherapy regimen

doi:10.2174/138620706776055458

From there it reaches the cytosol via VDAC [15,121] or it is dismutated by IMS-located SOD1 to H 2 O 2 , which reaches the cytosol via diffusion or aquaporins [85,122,123,124,125,126]

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