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Cancer 104 , 735744

GAP alleviated mitochondrial dysfunction, as shown by mitigation of mitochondrial membrane potential loss, ATP depletion, Ca2+ overload and mitochondrial fragmentation, together with upregulation of SIRT1, AMPK1 and PGC-1 mRNA expression

found elevated metabolites such as betaine, shikimic acid, and estrone 3-sulfate, which correlated with gut microbes such as Streptococcus and Enterococcus, linking gut dysbiosis to myocarditis-induced metabolic disturbances (82)