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These transporters, such as LAT1 (SLC7A5) and CAT-1 (SLC7A1), mediate the uptake of essential amino acids (e.g., leucine, arginine) that activate the mTORC1 signaling pathwaya central hub for integrating nutrient availability with insulin secretion and glucose metabolism

Aggregate payments with the 5-percent cap using the proposed FY 2024 labor-related share percentages, the proposed FY 2024 relative weights, the proposed FY 2024 wage index for each hospital after adjusting the wage indexes under the low wage index hospital policy, and applied the same proposed proxy FY 2024 hospital readmissions payment adjustments and the proposed proxy FY 2024 hospital VBP payment adjustments applied previously