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The researchers therefore proposed that the ability of AHK-Cu to interact with VEGFR-2 may represent a key molecular feature underpinning its biological activity on promoting the growth of hair follicle cells and other structures

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76 For instance, AARS1 functions as an intracellular lactate sensor, directly binding lactate to form lactate-AMP, and mediates lactylation of K120/139 on p53 within its DNA-binding domain (DBD), which prevents the binding of p53 to DNA containing p53 response elements (p53RE-DNA) and subsequent p53 liquidliquid phase separation (LLPS)