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The HIF-1/vascular endothelial-derived growth factor (VEGF) signaling pathway plays an important role in hypoxia-induced EndoMT of human microvascular ECs [101], and 2-ME2 potentially inhibits EndoMT by suppressing this pathway

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In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration