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People often report injuries to their lower legs, knees, hips, and thighs

Dr Louise Newson, GP and Menopause Specialist, explains: "People find their tolerance changes because the way the liver mops up and clears toxins is negatively affected when oestrogen is low." [18] Studies suggest that perimenopausal hormonal changes can even lead to a 40% reduction in liver size, further slowing alcohol metabolism [19]

doi:10.1016/0304-4165(75)90205-6 42

PLoS Genet 15:e1007685 Sutani T, Kawaguchi T, Kanno R, Itoh T, Shirahige K (2009) Budding yeast Wpl1(Rad61)-Pds5 complex counteracts sister chromatid cohesion-establishing reaction