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Acute myeloblastic leukemia (AML) is an aggressive malignancy characterized by the clonal proliferation of primitive, immature hematopoietic stem cells in the blood and bone marrow, leading to ineffective erythropoiesis and bone marrow failure [22]

While found throughout the body, its more prominent in the liver and in fat cells

The formation of ice crystals can physically damage the delicate protein structure of a peptide, a process called denaturation

4: Sikiric P, Barisic I, Udovicic M, Lovric Bencic M, Balenovic D, Strinic D, Zivanovic Posilovic G, Uzun S, Vranes H, Krezic I, Lozic M, Stambolija V, Premuzic Mestrovic I, Beketic Oreskovic L, Oreskovic I, Strbe S, Sikiric S, Tomic L, Kordic M, Tvrdeic A, Seiwerth S, Boban Blagaic A, Skrtic A