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507 The brains of individuals with preclinical AD (PCAD) and AD exhibit oxidative damage to a variety of molecules, e.g., accumulation of protein carbonyls (PCs) in regions that are rich in A-peptide-containing SPs, increased lipid peroxidation in AD and PCAD hippocampi and elevated DNA damage

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doi: 10.1034/J.1399-6576.2000.440104.X 23 BasuS.ErikssonM

This process may facilitate the release of various mitochondrial components and their metabolic byproducts, which possess immunogenic characteristics, such as mitochondrial DNA (mtDNA) and cytochrome C, into the cytoplasm