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Furthermore, this pathway cross-talks extensively with other signaling cascades and is subject to regulation by epigenetic mechanisms such as miRNAs, thereby forming a multidimensional regulatory network

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Thirty days after the second dose, K18-hACE2 or K18-hACE2/B-KO mice were challenged intranasally with 5 10 4 PFU of SARS-CoV-2 (for the Wuhan strain, Delta and Omicron variant) and 5 10 3 PFU of SARS-CoV-2 (for the Gamma variant)

Based on structural models, it can be assumed that the MT molecule is composed of two binding domains, and , which are composed of Cys-clusters